Background: Abnormal Savda Munziq (ASMq) is a traditional prescription in Uyghur Medicine, and its treatment of\ncomplex diseases such as tumors and asthma has been proven to be effective in Uyghur medical clinical practice.\nThe efficacy-enhancing and toxicity-reducing properties of ASMq were studied on mice with transplanted cervical\ncancer (U27) tumors, which were treated with 5-fluorouracil (5-FU) in this work.\nMethods: To investigate the synergistic effect of ASMq and 5-FU on U27 cells, inhibitory effects on cell proliferation\nwere determined through a MTT assay. 48 Kunming mice which were randomly divided in to 6 groups: control group,\nmodel group, 5-FU group, 5-FU combine with ASMq low-dose group, 5-FU combine with ASMq medium-dose group,\nand 5-FU combine with ASMq high- dose group, the inhibition rate of the tumor, the viscera indexes, and the content\nof serum tumor necrosis factor-�± (TNF-�±), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were\ndetermined. The expression levels of transforming growth factor-�²1 (TGF-�²1) and human papillomavirus type 16 E2\n(HPV16 E2) protein were assessed by Western blot. Pathological changes in the liver were observed.\nResult: The inhibition rates of tumors, the 5-FU + ASMq.H group(80.64%), 5-FU + ASMq.M group (90.67%), 5-FU + ASMq.L\ngroup (72.03%) and 5-FU group (66.89%), clearly indicated that the effects of tumor inhibition. The thymus index and\nspleen index were increased, and the serum concentration of TNF-�± increased while ALT and AST concentrations were\ndecreased, and TNF-�± protein expression were increased while TGF-�²1 and HPV16 E2 were decreased. ASMq might can\nimprove livers central vein hyperemia and interstitial edema, and preserve the radial structure of the hepatic cords.\nConclusions: The results suggested that ASMq might reduce toxicity and enhance the efficacy of the chemotherapeutic\ndrug 5-fluorouracil in the treatment of cervical carcinoma.
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